The Dermalogica Melanopro Peel System is a clinical strength, two phase professional treatment designed to resurface the skin and address hyperpigmentation while supporting overall skin health.
It is formulated to treat concerns such as sun damage, fine lines and wrinkles, sun spots, post inflammatory hyperpigmentation (PIH), and superficial to mixed depth melasma. Unlike highly aggressive depigmentation protocols, Melanopro is positioned as a lower risk, regulation focused system that delivers visible results in approximately six weeks with minimal disruption to daily life.
The system works through a two phase approach that combines an in clinic professional peel with a structured home care regimen. Phase one involves the application of an Intensive Peeling Masque by a trained skin therapist, which remains on the skin for several hours before being removed at home.
Phase two consists of a six week at home programme using Dermalogica’s Continuous Resurfacing Cream, calming mist, and daily sun protection. This phased design allows for controlled resurfacing while maintaining barrier comfort, helping to minimise inflammation and sensitivity during the correction period.
Overall, Melanopro prioritises consistency, safety and long term skin health alongside visible brightening results and lower risk of post‑inflammatory complications.
MelanoPRO Opening Order
To stock MelanoPRO a minimum of 2 x MelanoPRO kits are required to purchase. Each kit has 4 inclinic treatments and homecare for your client, so you will have enough for 8 customers.
It also includes
8 x Post Procedure kits which includes SPF, Ultra Calming Cleanser and an additional Ultra Calming Mist.
Total investment $1514.00
Future purchases can be made individually and MelanoPRO kits are $629 for each 4 pack.
1. It down regulates melanin production inside the melanocyte
Melanin is produced inside melanocytes through a tightly regulated enzymatic pathway called melanogenesis, with tyrosinase as the rate limiting enzyme. One of Melanopro’s key actives, azelaic acid, acts as a competitive inhibitor of tyrosinase, meaning it interferes with the enzyme’s ability to convert tyrosine into melanin precursors. This directly reduces the amount of new melanin being made, without destroying melanocytes or inducing cytotoxic stress, which is especially important in pigment prone skin.
2. It blocks inflammatory and vascular signalling that overstimulates melanocytes
Pigment disorders like melasma are not driven by melanin alone, they are also fuelled by inflammation, UV induced mediators, and vascular signalling. Tranexamic acid, inhibits the plasmin/plasminogen pathway. When plasmin is activated in keratinocytes and the dermis, it triggers inflammatory cytokines and growth factors that stimulate melanocytes to produce excess pigment.
3. It limits transfer of pigment into visible skin layers
Even if melanin is produced, it must be transferred from melanocytes into keratinocytes to become visible on the skin surface. Niacinamide (vitamin B3) plays a crucial role here. Rather than inhibiting melanin synthesis, niacinamide reduces the transfer of melanosomes from melanocytes to surrounding keratinocytes.
4. It accelerates removal of existing pigmented keratinocytes
Melanopro also incorporates retinol, which acts at the epidermal level by increasing keratinocyte turnover and differentiation. Retinol helps pigmented keratinocytes move upward and shed more efficiently, physically removing melanin that has already been transferred into the epidermis. Additionally, retinoids have been shown to down regulate tyrosinase gene expression, further reducing melanogenesis over time.